Newcastle United’s reward for knocking out the Carabao Cup holders will see Manchester United travel to Chelsea in the quarter-finals, while record nine-time winners Liverpool host West Ham United.
In the other two consecutive ties on Wednesday, Everton welcome Fulham and Championship Middlesbrough host League One surprise package Port Vale while the remaining two non-Premier League sides meet.
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Newcastle beat last year’s winners 3-0 at Old Trafford on Wednesday and will now take on a struggling Chelsea after a much-needed win over Blackburn Rovers.
West Ham should travel to Anfield full of confidence after dispatching Arsenal comfortably 3-1 at the London Stadium.
Only three of the remaining eight teams – Liverpool, five-time winners Chelsea and 2004 winners Middlesbrough – have ever lifted the League Cup trophy before.
Port Vale reached the quarter-finals for the first time in their history with a 1-0 win over League Two Mansfield Town on Tuesday.
The quarter final matches will be held in the week of December. 18.
Carabao Cup Quarter Final Draw:
Everton vs Fulham
Chelsea vs Newcastle
Port Vale v Middlesbrough
Liverpool vs West Ham